The Laurens County Museum Association was organized in 2005, by various community leaders from different parts of Laurens County. Led by James Gambrell, this small group met at the Laurens County Library in July of that year to discuss the possibility of establishing a museum to preserve items of importance to Laurens County history. Within one year, this group purchased the building located at 205 West Laurens Street, secured grant funding, renovated the building, and opened the Laurens County Museum.

In 2012, John D. Witherspoon donated a beautiful and quite large set of bedroom furniture. It became immediately apparent that the pieces did not fit in the space the museum currently owned. Mr. Witherspoon had a solution! He purchased our new building located directly across from the Laurens County Courthouse and donated it to the Laurens County Museum Association. Although this building was large and prominently located, the Museum Association was taking on a huge renovation project. The museum originally located on West Laurens Street remained open during this complex and expensive renovation project.

It has long been the philosophy of the Laurens County Museum Association not to take out loans or acquire debt. Because of this, the work at the Witherspoon Building has taken a long time to complete. Major renovations were necessary to make the building usable and ADA accessible. Essentially, the museum had to be completely gutted when the Association acquired it, and work was done when money was available. The Laurens County Museum Association is deeply indebted to the late Tony Harper. Sadly, Tony passed away in 2019, but before he died, he bequeathed monies to the Laurens County Museum Association. This money was used to complete the work on the Witherspoon Building, redesign exhibits and move them to the new location. The grand opening was held on January 2, 2022.